代表性论文： 1. Zhang, R, Peppelenbosch Maikel P., Smits Ron, et al. Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling. Cancer Research. 2024 Feb 15.(中科院一区top， IF:11.2) 2. Li, Y.#, Zhang, R.#, et al. (2023). Hepatitis E virus infection remodels the mature tRNAome in macrophages to orchestrate NLRP3 inflammasome response. Proc Natl Acad Sci U S A, 120(25), e2304445120.(# equal contribution,中科院一区top，IF:12.8) 3. Zhang, R, Noordam, L, Ou, X, et al. The biological process of lysine-tRNA charging is therapeutically targetable in liver cancer. Liver International. 2021;41: 206– 219. (中科院二区， IF: 8.75). 4. Zhang, R, Hornung Bastian V. H., van den Hout Mirjam C. G. N., van Ijcken Wilfred F. J., Peppelenbosch Maikel P., Smits Ron. Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines. PLOS ONE, 2024, 19(6). 5. Ou X#, Ma B#, Zhang R#, Miao Z, Cheng A, Peppelenbosch MP, Pan Q. A simplified qPCR method revealing tRNAome remodeling upon infection by genotype 3 hepatitis E virus. FEBS Lett. 2020 Jun; 594(12): 2005-2015. (# equal contribution) 6. Li Y, Miao Z, Li P, Zhang R, Kainov DE, Ma Z, de Man RA, Peppelenbosch MP, Pan Q. Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1. Arch Virol. 2021 Jul;166(7):2005-2010. 7. Wang W, Liu P, Lavrijsen M, Li S, Zhang R, Li S, van de Geer WS, van de Werken HJG, Peppelenbosch MP, Smits R. Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines. Sci Rep. 2021 Apr 2;11(1):7470. 8. Liu J, Li P, Zhang R, Zhou G, Carrascosa LC, Sprengers D, IJzermans JNM, Smits R, Kwekkeboom J, van der Laan LJW, Peppelenbosch MP, Pan Q, Cao W. Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance. Cell Mol Gastroenterol Hepatol. 2021;11(2):407-431. 9. Li Y, Li P, Li Y, Zhang R, Yu P, Ma Z, Kainov DE, de Man RA, Peppelenbosch MP, Pan Q. Drug screening identified gemcitabine inhibiting hepatitis E virus by inducing interferon-like response via activation of STAT1 phosphorylation. Antiviral Res. 2020 Dec;184:104967 10. Jiaye Liu, Dave Sprengers, Ruyi Zhang, Guoying Zhou, Ron Smits, Jaap Kwekkeboom, Luc J.W. van der Laan, Maikel Peppelenbosch, Qiuwei Pan, Wanlu Cao.FRI488 - Modelling liver tumor organoids and cancer-associated fibroblasts interaction reveals the robust effects of stromal niche in cancer nurturing and treatment resistance. Journal of Hepatology. 2020; 73(1):S638-S63 11. Li P, Li Y, Wang Y, Liu J, Lavrijsen M, Li Y, Zhang R, Verstegen MMA, Wang Y, Li TC, Ma Z, Kainov DE, Bruno MJ, de Man RA, van der Laan LJW, Peppelenbosch MP, Pan Q. Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids. Sci Adv. 2022 Jan 21;8(3):eabj5908. 12. Li Y, Li P, He Q, Zhang R, Li Y, Kamar N, Peppelenbosch MP, de Man RA, Wang L, Pan Q. Niclosamide inhibits hepatitis E virus through suppression of NF-kappaB signalling. Antiviral Res. 2022 Jan;197:105228. 13. Gao K, Zong H, Hou K, Zhang Y, Zhang R, Zhao D, Guo X, Luo Y, Jia S. p53N236S Activates Autophagy in Response to Hypoxic Stress Induced by DFO. Genes (Basel). 2022 Apr 26;13(5):763 |
