吴兴德，博士，教授，博士生导师。2012年7月博士毕业于中国科学院昆明植物研究所，师从赵勤实研究员，毕业后留所工作任助理研究员。2017年1月晋升为副研究员，2022年3月作为高层次人引进到云南民族大学工作，同时入选云南民族大学“南菁计划”第六层次人才；2024年11月晋升为教授。目前主持国家自然科学基金项目4项（面上项目2项）和云南省基础研究项目2项（重点项目1项）、国家重大新药创制专项子任务1项；入选云南省高层次“青年拔尖”人才、中国科学院青年创新促进会会员、中国科学院“西部之光”人才培养计划；任《中草药》青年编委、Frontiers in Chemistry编委（review editor）、云南省药学会中药民族药专委会委员;以第一或通讯作者在Organic Letters、European Journal of Medicinal Chemistry、Organic Chemistry Frontiers等期刊发表SCI论文50余篇；获授权专利10件；获云南省科学技术奖励自然科学二等奖1项，广西科学技术奖励自然科学三等奖1项。

联系方式：wuxingdeymu@163.com

研究方向：中药、民族药、天然药物药效物质基础研究；活性天然产物结构修饰与合成

  科研项目

1、2024.01-2027.12，国家自然科学基金面上项目，32370423，50万，主持人，在研；

2、2023.01-2026.12，国家自然科学基金地区项目，22267022，33万，主持人，在研；

3、2018.01-2021.12，国家自然科学基金面上项目，81773611，57.6万，主持人，已结题；

4、2015.01-2017.12，国家自然科学基金青年科学基金项目，21402212，25万，主持人，已结题；

5、2019.07-2022.06，云南省基础研究重点项目，2019FA037，50万，主持人，已结题；

6、2016.01-2019.12，中国科学院青年创新促进会人才项目，70万，主持人，已结题；

7、2019.01-2023.12，云南省万人计划“青年拔尖人才”项目，2018-276，50万，主持人，已结题；

8、2015.10-2018.09，云南省应用基础研究面上项目，2015FB173, 10万，主持人，已结题；

9、2015.01-2017.12，中国科学院“西部之光”人才培养计划“西部博士”项目，10万，主持人，已结题。

代表性研究论文

[1] Wang, H. -Y; Shen, Y; Nie, W; Tu, W. -C; Huang, S; Wu, X. -D*; Clerodane diterpenoids from the vine stems of Fibraurea recisa Pierre and their hepatic gluconeogenesis inhibitory activity. Phytochemistry, 2025, 232, 114364.

[2] Tu, W.-C; Ding, L.-F; Song, L.-D; Li, Y.-J; Yan, R.-C; Wu, Y; Feng W.-Y; Wu, X. -D*; Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities. Phytochemistry, 2024, 225, 114189.

[3] Su, J.^#; Wang, D.-S.^#; Hu, G.-X.^#; Liu, Y.-Y.^#; Hu, M.; Chen, Y.; Wang, Q.-Q.; Yan, R.-C.; Wu, Y.; Li, Y.-J.; Ma, K.; Qi, Y.-Y.*; Ding, L.-F.*; Wu, X.-D.*, Anti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway. Phytochemistry, 2024, 222, 114105.

[4] Ding, L.-F.^#; Hu, G.-X.^#; Liu, Y.-Y.; Wang, Q.-H.; Li, Z.-J.; Shen, M.-X.; Zhu, G.-F. Wu, X.-D.*; Su, J.*, Eudesmane-type sesquiterpenoids from the aerial parts of Artemisia lavandulaefolia and their anti-pancreatic cancer activities, 2023, Phytochemistry, 216, 113871.

[5] Wu, X.-D; Huang, S; Shi, Y; Shen, Y; Tu, W.-C; Leng, Y*; Zhao, Q.-S*; Design, synthesis, and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis. Eur. J. Med. Chem., 2022, 232, 114171.

[6] Wu X.-D; Ding, L. F; Li, W. -Y; Cheng, B; Lei, T; Zhou, H.- F; Zhao, Q.- S*; Hypoestins A–D: highly modified fusicoccane diterpenoids with promising Cav3.1 calcium channel inhibitory activity from Hypoestes purpurea. Org. Chem. Front., 2022, 9: 3075-3083.

[7] Deng, Z.-T.^#; Wu, X.-D.^#; Yuan, Z.-F.; Yu, N.-R.; Ou, Y.-F.; Zhao, Q.-S.*, Total synthesis of huperserratines A and B. Org. Chem. Front., 9, 3664-3668, 2022.

[8] Wu, X.-D; Ding, L.-F; Chen, B; Li, X.-N; Peng, L.-Y; Zhao, Q.-S*, Cunlanceloic acids A-D: unprecedented labdane diterpenoid dimers with AChE inhibitory and cytotoxic activities from Cunninghamia lanceolata. Org. Chem. Front., 2021, 8, 5777-5784.

[9] Wang, L. -Y; Li, W. -Y; Zhou, H.- F; Zhao, X. -Y; Li, X. -N; Wu, X. -D*; Zhao, Q. -S*; Spiroligustolides A and B: Two pairs of enantiomeric spiro-orthoester-containing phthalide dimers as Cav3. 1 calcium channel inhibitors from Ligusticum Chuanxiong Hort. Bioorg. Chem. 2022, 123, 105749.

[10] Tu, W.-C; Ding, L.-F; Peng, L.-Y; Song, L.-D; Wu, X.-D*; Zhao, Q.-S.*; Cassane diterpenoids from the seeds of Caesalpinia bonduc and their nitric oxide production and alpha-glucosidase inhibitory activities. Phytochemistry, 2022, 193, 112973.

[11] Liu, J.^#; Wu, X.-D.^#; Li, W.^#; Yuan, Z.^#; Yang, K.; Zhao, Q.-S., Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism. Bioorg. Chem., 2021, 112, 104963.

[12] Wu, X.-D; Li, X.-N; Peng, L.-Y; Zhao, Q.-S*; Huperserratines A and B, two macrocyclic Lycopodium alkaloids with an unusual skeleton from Huperzia serrata. J. Org. Chem., 2020, 85, 6803-6807.

[13] Tu, W.-C.; Qi, Y.-Y.; Ding, L.-F.; Yang, H.; Liu, J.-X.; Peng, L.-Y.; Song, L.-D.; Gong, X.; Wu, X.-D.*; Zhao, Q.-S.*, Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides. Phytochemistry, 2019, 161, 86-96.

[14] Fan, M.; Luo, D.; Peng, L.-Y.; Li, X.-N.; Wu, X.-D.*; Ji, X.*; Zhao, Q.-S.*, Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects. Phytochemistry, 2019, 166, 112065.

[15] Ding, L.-F.^#; Su, J.^#; Pan, Z.-H.; Zhang, Z.-J.; Li, X.-N.; Song, L.-D.; Wu, X.-D.*; Zhao, Q.-S.*. Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora, Phytochemistry, 2018, 155, 182-190.

[16] Wu, X.-D; Luo, D; Tu, W.-C; Deng, Z.-T; Chen, X.-J; Su, J; Ji, X*; Zhao, Q.-S*; Hypophyllins A-D, labdane-type diterpenoids with vasorelaxant activity from Hypoestes phyllostachya "Rosea". Org. Lett., 2016, 18, 6484-6487.

[17] Wu, X.-D.; Ding, L.-F.; Tu, W.-C.; Yang, H.; Su, J.; Peng, L.-Y.; Li, Y.; Zhao, Q.-S.*, Bioactive sesquiterpenoids from the flowers of Inula japonica. Phytochemistry, 2016, 129, 68-76.

[18] Wu, X.-D.; He, J.; Li, X.-Y.; Dong, L.-B.; Gong, X.; Song, L.-D.*; Li, Y.; Peng, L.-Y.; Zhao, Q.-S.*, Diterpenoids from the twigs and leaves of Fokienia hodginsii. J. Nat. Prod., 2013, 76, 1032-1038.