姓名：涂文超 （博士）

研究方向：天然药物化学

电子邮箱：tuwenchao@ymu.edu.cn

个人简介：主要聚焦中药和民族药药效物质的发现、结构修饰以及丰产化合物的开发利用；其中3个二萜类化合物被Natural Product Reports评为热点化合物。以第一作者在Chinese Chemical Letters、Organic Chemistry Frontiers、Journal of Natural Products、Bioorganic chemistry、Phytochemistry等期刊发表SCI论文10余篇；获授权专利1项；主持教育厅青年人才专项1项。

一、代表性论文：

1.Wen-Chao Tu^‡, Xing-Jie Zhang^‡, Ying-Xin Zhao^‡, Wei-Chi Chen, Xing-Yu Zhang, Chang-Lin Yang, Muhammad Aurang Zeb, Xiao-Li Li, Kaunda-Joseph Sakah, Rui-Han Zhang, Liu Mei-Feng*, Xiao Wei-Lie*. Diterpenoids with a novel 6/5-5 spiro tricyclic skeleton from Orthosiphon wulfenioides and their NLRP3 inflammasome inhibitory activity. Organic Chemistry Frontiers. 2023, 10, 2898–2906. (IF=5.5, 中科院1区, JCR 1区, 封面文章)

2.Wen-Chao Tu^‡, Yong-Xiang Huang^‡, Yuan-Lin Kong, Bo Li, Bin-Bao Wang, Tian-Hao Dong, Wei-Chi Chen, Muhammad Aurang Zeb, Xiao-Li Li*, Mei-Feng Liu*, Chang-Bo Zheng*, Wei-Lie Xiao*. Biswulfenioidins A–E, dioxygen-bridged abietane-type diterpenoid dimers with anti-Zika virus potential from Orthosiphon wulfenioides. Organic Chemistry Frontiers. 2024, 13, 2052-4129. (IF=4.6, 中科院2区)

3.Yingjie Wang^‡, Peng Tang^‡, Wenchao Tu^‡, Qi Gao^‡, Cuizhu Wang^‡, Luying Tan^‡, Lixin Zhao^‡, Hongye Han^‡, Liefeng Ma^‡, Kouharu Otsuki^‡, Weilie Xiao*, Wenli Wang*, Jinping Liu *, Yong Li*, Zhajun Zhan*, Wei Li*, Xianli Zhou*, Ning Li*. Highly anticipated natural diterpenoids as an important source of new drugs in 2013–2023. Chinese Chemical Letters. 2025, 36, 109955. (IF=9.1, 中科院1区, Top)

4.Wen-Chao Tu^‡, Ying-Xin Zhao^‡, Chang-Lin Yang, Xing-Jie Zhang, Xiao-Li Li, Kaunda-Joseph Sakah, Rui-Han Zhang, Xiao Wei-Lie*, Liu Mei-Feng*. Abietane diterpenoids from Orthosiphon wulfenioides with NLRP3 inflammasome inhibitory activity. Bioorganic Chemistry. 2023, 136, 106534. (IF=5.3, 中科院1区)

5.Wen-Chao Tu^‡, Yong-Xiang Huang^‡, Bo Li, Ying-Jie Jiang, Muhammad Aurang Zeb, Xing-Jie Zhang, Xiao-Li Li, Rui-Han Zhang, Xiao Wei-Lie*, Zheng Chang-Bo*, Liu Mei-Feng*. Wulfenioidins D−N, Structurally Diverse Diterpenoids with Anti-Zika Virus Activity Isolated from Orthosiphon wulfenioides. Journal of Natural Products. 2023, 86, 2348–2359. (IF=5.1, 中科院2区)

6.Wen-Chao Tu^‡, Peng-Yun Yang^‡, Xing-Jie Zhang^‡, Yuan-Lin Kong, Bo Li, Hui-Juan Wang, Muhammad Aurang Zeb, Xiao-Li Li*, Mei-Feng Liu*, Wei-Lie Xiao*. Bioactivity-guided isolation of potent inflammasome and mitochondria damage inhibitory diterpenoids from Orthosiphon wulfenioides, Phytochemistry, 2024, 230, 114335. (IF=3.2, 中科院2区)

7.Wen-Chao Tu^‡, Lin-Fen Ding^‡, Liu-Dong Song, Yong-Jiao. Li, Run-Chun Yan, Yun Wu, Wer-Yang Feng and Xing-De Wu, Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities, Phytochemistry, 2024, 225, 114189. (IF=3.2, 中科院2区)

8.Wen-Chao Tu^‡, Lin-Fen Ding, Li-Yan Peng, Liu-Dong Song, Xing-De Wu *, Qin-Shi Zhao *. Cassane diterpenoids from the seeds of Caesalpinia bonduc and their nitric oxide production and α-glucosidase inhibitory activities. Phytochemistry. 2022, 193, 112973. (IF=4.0, 中科院2区)

9.Wen-Chao Tu^‡, Yan-Yan Qi, Lin-Fen Ding, Hui Yang, Jiang-Xin Liu, Li-Yan Peng, Liu-Dong Song, Xun Gong, Xing-De Wu *, Qin-Shi Zhao *. Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides. Phytochemistry. 2019, 161: 86–96. (IF=3.0, 中科院2区)

二、申请及授权专利

1. 具有NLRP3抑制活性的鸡脚参酮A及其衍生物与应用，申请号：202310131400.5，发 明 人：刘美凤，涂文超，肖伟烈，张兴杰，赵莹欣，李晓莉，张芮菡 。授权号：CN 116283533 B

2. 兼具逆转线粒体损伤和抗炎活性的鸡脚参酮L−W及其用途，申请号：CN 202410430000.9，发明人：刘美凤，涂文超，李晓莉，杨鹏云，肖伟烈，张兴杰，张芮菡，孔苑琳，李博 。

3. 具有抗寨卡病毒活性的二聚鸡脚参素A–E及taxodascens J的二萜二聚体化合物及其制备方法和用途，申请号： CN 202410430000.9 ，发明人：肖伟烈，涂文超，刘美凤，郑昌博，黄勇祥，李晓莉，张芮菡，张兴杰，孔苑琳，李博。

三、科研项目

1. 2025.03-2027.02, 云南省教育厅青年人才基础研究专项, 2025J0490, 4万, 主持

2. 2025.07-2026.07, 云南民族大学引进人才科研启动经费, 15万, 主持