Bromide-catalyzed oxo-amination of alkenes towards the synthesis of α-amine ketones under photoelectrocatalysis conditions

By: Zhi-Min Zong, Mingxu Wang, Xiao-Jing Zhao, Yonghui He

DOI：https://doi.org/10.1039/D4QO00369A

Published：2024-05-14

Abstract

An efficient and novel bromide-catalyzed oxo-amination of aryl alkenes towards the synthesis of α-amine ketones using air as the oxygen source under photoelectrocatalysis conditions was developed. The reaction was characterized by simple operation, a broad substrate scope, high atom economy, and mild reaction conditions. The mechanistic results suggested that the generation of 2-bromo-1-phenylethanone via oxo-bromination of aryl alkenes was the key step in this transformation.